Andrew Clayton-Payne read History of Art and Italian at the University of Bristol. He set up as a private dealer in Old Bond Street in 1997 following eight years as Head of British Watercolours and Drawings at Christie's.

He deals discreetly in 17th-, 18th- and 19th century English and European pictures from his second-floor gallery at 14 Old Bond Street. Situated in Mayfair, Andrew Clayton-Payne is in the centre of London's art dealing district and close to the Royal Academy of Arts on Piccadilly.

A highly respected specialist, Andrew Clayton-Payne is a published author with two books on 19th Century painting, including the best selling Victorian Flower Gardens published by Weidenfeld & Nicolson in 1988. He has also written on a wide variety of subjects for magazines such as Country Life and has acted as an independent adviser to the Heritage Lottery Fund, the Acceptance in Lieu panel and the Reviewing Committee on the Export of Works of Art.

Andrew Clayton-Payne is a member of the Society of London Art Dealers.